PPT Slide

Sample size calculations.

P1-P2 = 0.08

n = 483

1+(m-1)? = design effect

m = 53

? = 0.023616322

1+(m-1)? = 2.228

adjusted n = 483*2.228

= 986 patients per group

N.B. - if n = 986 and m = 53, then the number of clusters per group = 18.6…