Grants

2016-2021 Doig GS, Simpson F, Ward C, Laviano A, Arthur C, Kerridge I, Angstmann K and Heighes P. Prophylactic early parenteral nutrition in patients undergoing hematopoietic cell transplantation: A multi-centre randomised controlled trial. $1,131,673.40.

2013 Doig GS Update of the Australian and New Zealand Bi-National Evidence-based guidelines for nutritional support in critical illness. Nestle Healthcare Nutrition, Australia, $78,100.

2012-2016 Doig GS Academic Audit of Current Nutrition Practices in ICUs throughout the World: A web-based quality improvement initiative.

    Baxter Healthcare Pty Ltd. Sydney $6,500
    Baxter Healthcare Ltd. United States $6,500
    Nestle Healthcare Nutrition, South Africa $6,500
.

2012-2014 Doig GS Nephro-protective effects of L-amino acids in cardiac surgery patients: An add-on study for a pilot randomised controlled trial Sydney Medical School Cardiothoracic Surgery Research Grant Scheme, $27,195.

2012-2014 Doig GS, Brereton J, Pollock C, Sweetman EA, Simpson F, Heighes, PT and Chesher D Nephro-protective effects of L-amino acids in cardiac surgery patients: A pilot randomised controlled trial. North Shore Heart Research Foundation, $144,168.

2011-2012 Doig GS and Sweetman EA. A systematic review and meta-analysis of outcomes attributable to off-pump coronary artery bypass surgery without aortic manipulation compared to on-pump coronary artery bypass surgery. Sydney Medical School Cardiothoracic Surgery Research Grant Scheme, $24,000.

2010-2015 Bellomo R, Myburgh J, Finfer SR, Cooper DJ, Lipman J, Doig GS and Hillman K. ANZICS Centre for Clinical Trials. National Health & Medical Research Council Enabling Grant, $2,500,000

2010-2014 Doig GS, Simpson F, Caterson I, Davies AR, McLean A, Bellomo R, Chesher D, Ferrie S, Harrigan P, Nair P and Nalos M. Management of refeeding syndrome in critical illness: An AuSPEN endorsed multicentre clinical trial. National Health & Medical Research Council Project Grant  $1,308,800

2010-2013 Doig GS, Bellomo R, Davies AR, Simpson F, Reade M, Pollock C, Chesher D, Harrigan P, Devarajan, P, Botha J and Sweetman EA. Nephro-protective effects of L-amino acids in critically ill patients: A multi-centre randomised controlled trial. National Health & Medical Research Council Project Grant $829,300

2010-2012 Doig GS, Simpson F, Sweetman EA and Bellomo R. The effects of amino acid supplementation in critically ill patients at high risk of clinically significant renal dysfunction: Product support for a multi-centre randomised controlled trial. Baxter Health Care Pty Ltd, $142,920

2010 Doig GS and Simpson F. Provision of parenteral nutrition to support a Level I RCT of early parenteral nutrition. Fresenius Kabi Deutschland GmbH. $110,000.

2009 Doig GS, Pollock C and Simpson F. Redundant Array of Inexpensive Drives (RAID) to facilitate secure and redundant data storage for Northern Clinical School web-based clinical trials. Research Infrastructure Block Grant, Northern Clinical School, University of Sydney, $2,539.

2009-2010 Doig GS and Sweetman EA. A systematic review and meta-analysis of outcomes attributable to off-pump coronary artery bypass surgery without aortic manipulation. Sydney Medical School Cardiothoracic Surgery Research Grant Scheme, $20,000.

2009-2010 Doig GS, Simpson F, Sweetman EA and Bellomo R. Background work in preparation for a multi-centre randomised controlled trial: The effects of amino acid supplementation in critically ill patients at high risk of clinically significant renal dysfunction. Baxter Health Care Pty Ltd, $20,000.

2008 Doig GS and Pollock C. Robust, redundant server cluster to support Northern Clinical School web-based clinical trials. Research Infrastructure Block Grant, Northern Clinical School, University of Sydney, $20,000.

2006-2011 Doig GS, Cooper DJ, Finfer SR, Simpson F, Solano T, Peake S and Davies A. Early parenteral nutrition vs. standard care in the critically ill patient: A Level I randomised controlled trial. National Health & Medical Research Council Project Grant, $1,812,750.

2006-2010 Doig GS and Simpson F. Provision of parenteral nutrition to support a Level I RCT of early parenteral nutrition. Fresenius Kabi Deutschland GmbH. $418,900.

2006-2009 Simpson F and Doig GS. The clinical utility of body composition spectroscopy (using the BodyScout monitor) in the critically ill: An add-on study to a Level I RCT. Fresenius Kabi Deutschland GmbH. $10,000 in equipment.

2006 Doig GS, Finfer SR, Piper R and Raper R. Critical care research network upgrade. Research Infrastructure Block Grant, Northern Clinical School, University of Sydney, $30,000.

2005-ongoing Doig GS and Simpson F. Background work for an ANZICS CTG endorsed Level I randomised controlled trial: Early parenteral nutrition vs. standard care in the critically ill patient:

Baxter Healthcare Pty Ltd. Sydney, $100,000.

Fresenius Kabi Deutschland GmbH, $138,775.

2005-2009 Bellomo R, Myburgh J, Finfer SR, Cooper DJ, Lipman J, Doig GS and Hillman K. ANZICS Centre for Clinical Trials. National Health & Medical Research Council Enabling Grant, $1,516,877.22

2004-2005 Davies AR, Bellomo R, Cooper J, Doig GS, Finfer S. A Randomised Controlled Trial Comparing Jejunal and Gastric Nutritional Support in Critically Ill Patients. Australian and New Zealand Intensive Care Foundation, $154,000.

2003-2005 Doig GS, Finfer S, Simpson F, Dobb G, Mitchell I and Davies A. Developing and evaluating evidence-based guidelines for nutritional support in the intensive care unit: A cluster randomised trial. Australian and New Zealand Intensive Care Foundation, $548,000.

2001-2003 Hillman K, Bellomo R, Finfer S and Doig GS. Medical early response intervention and therapy (MERIT): A cluster randomised trail. National Health and Medical Research Council and State and National Governments. $1,124,429.

Publications

Heighes PT, Doig GS and Simpson F. Timing and Indications for Enteral Nutrition in the Critically Ill In: Nutrition Support for the Critically Ill. David Seres and Charles Van Way (Eds). Springer-Verlag, 2016, pp 55-62.

Doig GS, Simpson F, Heighes PT, Bellomo R, Chesher D, Caterson ID, Reade MC, and Harrigan PWJ. Restricted vs. continued normal caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, multicentre, and single-blind controlled trial. Lancet Respiratory Medicine 2015;3(12):943-952.

Doig GS, Simpson F, Bellomo R, Heighes PT, Sweetman EA,Chesher D, Pollock C, Davies A, Botha J, Harrigan P, Reade MC. Intravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial. Intensive Care Med 2015;41:1197-1208.

Doig GS and Simpson F. Understanding clinical trials: Emerging methodological issues. Intensive Care Med 2014 Oct;40(11):1755-1757

Doig GS and Simpson F. Hydroxyethyl starch 130/0.42 for bolus resuscitation in severe sepsis: Long term follow-up, confidence intervals and clinically important differences in outcomes [Editorial]. Intensive Care Med 2014 Jul;40(7):1036-8

Heighes PT and Doig GS. Intensive Care Specialists' knowledge, attitudes and professional use of published research evidence: A mail out questionnaire survey of appropriate use of research evidence in clinical practice. Journal of Critical Care 2014 Feb;29(1):116-22.

Doig GS, Chevrou-Séverac H, Simpson F. Early enteral nutrition in critical illness: a full economic analysis using US costs. Clinicoecon Outcomes Res. 2013 Aug 23;5:429-36.

Doig GS, Simpson F; Early PN Trial Investigators Group. Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a full economic analysis of a multicenter randomized controlled trial based on US costs. Clinicoecon Outcomes Res. 2013 Jul 22;5:369-79.

Doig GS, Simpson F, Sweetman EA, Finfer SR, Cooper DJ, Heighes PT, Davies AR, O'Leary M, Solano T, Peake S; Early PN Investigators of the ANZICS Clinical Trials Group. Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA 2013 May 22;309(20):2130-8

Doig GS. Parenteral vs enteral nutrition in the critically ill patient: additional sensitivity analysis supports benefit of early parenteral compared to delayed enteral nutrition. Intensive Care Med 2013 Feb 14 DOI: 10.1007/s00134-013-2865-5

Davies AR, Morrison SS, Bailey MJ, Bellomo R, Cooper DJ, Doig GS, Finfer SR, Heyland DK; ENTERIC Study Investigators; ANZICS Clinical Trials Group. A multicenter, randomized controlled trial comparing early nasojejunal with nasogastric nutrition in critical illness. Crit Care Med. 2012 Aug;40(8):2342-8.

Simpson F and Doig GS. Enteral nutrition in critical illness. In: Encyclopedia of Intensive Care Medicine. 1st Edition, JL Vincent and J Hall eds. Springer-Verlag, Heidelberg 2 January 2012. ISBN 978-3-642-00417-9.

Sweetman EA and Doig GS. Failure to report protocol violations in clinical trials: A threat to internal validity? Trials 2011, 12:214 DOI: 10.1186/1745-6215-12-214

Doig GS and Heighes PT. A Change Management Perspective on a Novel Meta-Analysis: Early Enteral Nutrition in Trauma Patients. ICU Management Forum, 2011;11(3):26-29.

Doig GS, Simpson F, Sweetman EA and Heighes PT  on behalf of the Early PN Trial Management Committee. Statistical Analysis Plan for a multi-centre randomised controlled trial: Early parenteral nutrition vs. standard care in patients not expected to be fed within 24 h of ICU admission. EvidenceBased.net, Sydney, Australia 2011. DOI: 10.4451/EarlyPN_SAP

Misfeld M, Brereton RJL, Sweetman EA, and Doig GS. Neurological complications after off-pump coronary artery bypass surgery with and without aortic manipulation: meta-analysis of 11,398 cases from 8 studies. The Journal of Thoracic and Cardiovascular Surgery 2011, [Epub ahread of print, 29th Jan].

Simpson F and Doig GS. Anthropometric Procedures Manual for a multi-centre randomised controlled trial: Early parenteral nutrition vs. standard care in patients not expected to be fed within 24 h of ICU admission. EvidenceBased.net, Sydney, Australia 2011. DOI: 10.4451/EarlyPN_APM

Doig GS, Heighes PT, Simpson F and Sweetman EA. Early enteral nutrition reduces mortality in trauma patients requiring intensive care: A meta-analysis of randomised controlled trials. Injury 2011;42(1):50-56

Simpson F and Doig GS. Enteral nutrition in critical illness. In: Encyclopedia of Intensive Care Medicine. JL Vincent and J Hall eds. Springer-Verlag, Heidelberg (10 Jan 2010).

Doig GS and Simpson F. Should we use feeding guidelines in the ICU? A review of the evidence. Netherlands Journal of Critical Care 2010;14(2):92-97.

Heighes PT, Doig GS, Sweetman EA, and Simpson F. An overview of evidence from systematic reviews evaluating early enteral nutrition in critically ill patients: more convincing evidence is needed. Anaesthesia and Intensive Care 2010;38(1):167-174.

Simpson F, Sweetman EA and Doig GS. A Systematic Review of Techniques and Interventions for Improving Adherence to Inclusion and Exclusion Criteria During Enrolment into Randomised Controlled Trials. Trials 2010 Feb 23;11:17.

Doig GS, Heighes PT, Simpson F, Sweetman EA and Davies AR. Enteral nutrition within 24 h of ICU admission significantly reduces mortality: A meta-analysis of RCTs. Intensive Care Medicine 2009 Dec;35(Issue 12):2018-2027.

Doig GS, Simpson F and Sweetman EA. Evidence-based nutrition support in the intensive care unit: An update on reported trial quality. Current Opinion in Clinical Nutrition and Metabolic Care 2009 12(2):201-6.

Smith RC, Ledgard JP, Doig GS, Smith SF and Chesire D. An effective automated nutrition screen for hospitalised patients. Nutrition 2009 Mar;25(3):309-15.

Doig GS and Simpson F. General Treatment Concepts: Parenteral Nutrition. In: Critical Care Nephrology, 2nd Edition. Bellomo, Ronco and Kellum Eds. Elsevier, Philadelphia 2009.

Doig GS, Simpson F, Finfer S, Delaney A, Davies AR, Mitchell I and Dobb G for the Nutrition Guidelines Investigators of the ANZICS Clinical Trials Group. Effect of evidence-based feeding guidelines on mortality of critically ill patients: a cluster randomized controlled trial. JAMA 2008 Dec 17;300(23):2731-41.

Simpson F and Doig GS. The relative effectiveness of practice change interventions in overcoming common barriers to change: A survey of 14 hospitals with experience in implementing evidence-based guidelines. Journal of Evaluation in Clinical Practice 2007 Oct;13(5):709-15.

Doig GS and Simpson F. Why we like randomised controlled trials! In: Critical Care Update 2006, V. Nayyar, JV Peter, Roop Kishen and S Srinivas Eds., Jaypee Brothers, New Delhi 2007.

Doig GS, Simpson F. With caveats, varying the block size can adequately conceal the allocation sequence: authors' response. J Crit Care. 2006 Jun;21(2):229-30.

Doig GS and Simpson F. Early enteral nutrition in the critically ill: Do we need more evidence or better evidence? Curr Opin Crit Care 2006;12(2):126-30.

Doig GS and Simpson F. Randomization and allocation concealment: A practical guide for researchers. J Crit Care 2005;20(2):187-193.

Evidence-Based Guidelines for Nutritional Support of the Critically Ill: Results of a Bi-National Guideline Development Conference. First Edition. Doig GS and Simpson F. EvidenceBased.net, Sydney, Australia 2005. (ISBN 0-9756039-1-4).

Simpson F and Doig GS.Parenteral vs. enteral nutrition in the critically ill patient: A meta-analysis of trials using the intention to treat principle. Intensive Care Med 2005;31(1):12-23.

Doig GS, Simpson F and Delaney AP. A review of the true methodological quality of nutritional support trials conducted in the critically ill: Time for improvement. Anesthesia & Analgesia 2005;100(2):527-33.

Martin CM, Doig GS, Heyland DK, Morrison T and Sibbald WJ. Multicenter, cluster randomized clinical trial of algorithms for critical care enteral and parenteral therapy (ACCEPT). CMAJ 2004;170(2):197-204.

Doig GS and Simpson F. Efficient literature searching: A core skill for the practice of evidence-based medicine. Intensive Care Medicine 2003;29:2119-2127. Epub Sep 3, 2003.